Interplay of ryanodine receptor distribution and calcium dynamics |
| |
Authors: | Izu Leighton T Means Shawn A Shadid John N Chen-Izu Ye Balke C William |
| |
Affiliation: | Department of Internal Medicine, University of Kentucky, School of Medicine, Lexington, Kentucky 40536-0509, USA. leightonizu@uky.edu |
| |
Abstract: | Spontaneously generated calcium (Ca2+) waves can trigger arrhythmias in ventricular and atrial myocytes. Yet, Ca2+ waves also serve the physiological function of mediating global Ca2+ increase and muscle contraction in atrial myocytes. We examine the factors that influence Ca2+ wave initiation by mathematical modeling and large-scale computational (supercomputer) simulations. An important finding is the existence of a strong coupling between the ryanodine receptor distribution and Ca2+ dynamics. Even modest changes in the ryanodine receptor spacing profoundly affect the probability of Ca2+ wave initiation. As a consequence of this finding, we suggest that there is information flow from the contractile system to the Ca2+ control system and this dynamical interplay could contribute to the increased incidence of arrhythmias during heart failure. |
| |
Keywords: | |
本文献已被 ScienceDirect PubMed 等数据库收录! |
|