线粒体融合蛋白2与心血管疾病

线粒体融合蛋白2(mitofusin2,Mfn2)不仅是一种不可或缺的调控线粒体形态和功能的动力素(dynamin)相关蛋白,还是一个重要的细胞内信号分子,参与调控细胞增殖、分化、凋亡等生命过程。Mfn2与高血压、冠状动脉腔内成形术后再狭窄、动脉粥样硬化、心肌肥厚、心肌氧化损伤等多种心血管疾病的病理生理过程密切相关,并通过调节物质代谢影响糖尿病和胰岛素抵抗等的发病。此外,Mfn2还可能是心血管疾病的一个重要的分子标志和治疗靶分子。

Mitochondrial fusion protein Mfn2 and cardiovascular diseases

Mitofusin 2(Mfn2)is a mitochondrial dynamin-related protein involved in the mitochondrial fusion reaction and is also connected to an altered mitochondrial energy supply. Mfn2 is a signaling molecule,plays an important role in cell proliferation,differentiation and apoptosis,which participates in the pathophysiology of several cardiovascular diseases,such as hypertension,restenosis after angioplasty,atherosclerosis,cardiac hypertrophy,and cardiac oxidative stress injury. Regulating the mitochondria-related ...