Mutagenicity of four hair dyes in Drosophila melanogaster. |
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Authors: | W G Blijleven |
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Institution: | Department of Radiation Genetics and Chemical Mutagenesis, Sylvius Laboratories of the State University of Leiden, Wassenaarseweg 72, Leiden, The Netherlands |
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Abstract: | The hair dye constituents p-phenylenediamine, 2,4-diaminoanisole sulfate, 2,4-diaminotoluene and 4-nitro-0-phenylenediamine were tested for mutagenicity in Drosophila melanogaster. The compounds were given orally to adult males. The induction of sex-linked recessive lethal mutation was used as a measure of mutagenicity. All four of the dyes tested were mutagenic with a peak mutagenic activity in metabolically active germ cells (spermatids and spermatocytes). |
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