Compartmentalised expression of Delta-like 1 in epithelial somites is required for the formation of intervertebral joints |
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Authors: | Ingeborg Teppner Sonja Becker Martin Hrabé de Angelis Achim Gossler Johannes Beckers |
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Affiliation: | (1) GSF – National Research Center for Environment and Health, GmbH, Institute of Experimental Genetics, Ingolstaedter Landstr.1, 85764 Neuherberg, Germany;(2) Medizinische Hochschule Hannover, Institute for Molecular Biology, Carl-Neuberg-Str.1, 30625 Hannover, Germany |
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Abstract: | Background Expression of the mouse Delta-like 1 (Dll1) gene in the presomitic mesoderm and in the caudal halves of somites of the developing embryo is required for the formation of epithelial somites and for the maintenance of caudal somite identity, respectively. The rostro-caudal polarity of somites is initiated early on within the presomitic mesoderm in nascent somites. Here we have investigated the requirement of restricted Dll1 expression in caudal somite compartments for the maintenance of rostro-caudal somite polarity and the morphogenesis of the axial skeleton. We did this by overexpressing a functional copy of the Dll1 gene throughout the paraxial mesoderm, in particular in anterior somite compartments, during somitogenesis in transgenic mice. |
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