Systematic analysis of the regulation of type three secreted effectors in <Emphasis Type="Italic">Salmonella enterica</Emphasis> serovar Typhimurium |
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Authors: | Yakhya Dieye Jessica L Dyszel Rebin Kader Brian MM Ahmer |
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Institution: | (1) Biodesign Institute, Arizona State University, 85287 Tempe, AZ, USA;(2) Department of Microbiology, The Ohio State University, 43210 Columbus, OH, USA |
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Abstract: | Background The type III secretion system (TTSS) is an important virulence determinant of Gram-negative bacterial pathogens. It enables
the injection of effector proteins into the cytosol of eukaryotic cells. These effectors ultimately manipulate the cellular
functions of the infected organism. Salmonella enterica serovar Typhimurium encodes two virulence associated TTSSs encoded by the Salmonella Pathogenicity Islands (SPI) 1 and 2 that are required for the intestinal and systemic phases of the infection, respectively.
However, recent studies suggest that the roles of these TTSSs are not restricted to these compartments. The regulation of
TTSSs in Salmonella is very complex with several regulators operating to activate or to repress expression depending on the environmental conditions. |
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