DAVID Knowledgebase: a gene-centered database integrating heterogeneous gene annotation resources to facilitate high-throughput gene functional analysis |
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| Authors: | Brad T Sherman Da Wei Huang Qina Tan Yongjian Guo Stephan Bour David Liu Robert Stephens Michael W Baseler H Clifford Lane Richard A Lempicki |
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| Institution: | (1) Laboratory of Immunopathogenesis and Bioinformatics, Clinical Services Program, SAIC-Frederick, Inc., National Cancer Institute at Frederick, Frederick, MD 21702, USA;(2) Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA;(3) Advanced Biomedical Computing Center, SAIC-Frederick, Inc., National Cancer Institute at Frederick, Frederick, MD 21702, USA;(4) Bioinformatics and Scientific IT Program, NIAID Office of Technology Information Systems, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA;(5) Clinical Services Program, SAIC-Frederick, Inc., National Cancer Institute at Frederick, Frederick, MD 21702, USA |
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| Abstract: | Background Due to the complex and distributed nature of biological research, our current biological knowledge is spread over many redundant
annotation databases maintained by many independent groups. Analysts usually need to visit many of these bioinformatics databases
in order to integrate comprehensive annotation information for their genes, which becomes one of the bottlenecks, particularly
for the analytic task associated with a large gene list. Thus, a highly centralized and ready-to-use gene-annotation knowledgebase
is in demand for high throughput gene functional analysis. |
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