Exploring disorder in the human charged biased proteins |
| |
Authors: | Mouna Choura Ahmed Rebaï |
| |
Institution: | 1. Laboratory of Plant Protection and Improvement, Center of Biotechnology of Sfax, University of Sfax, Sfax, Tunisia;2. Molecular and Cellular Diagnosis Processes, Centre of Biotechnology of Sfax, University of Sfax, Sfax, Tunisia |
| |
Abstract: | A considerable interest has been put in the identification of biased regions in proteins. These regions are frequently associated with a structural role in the cell and particularly with protein disorder. Here, we have investigated the intrinsically disordered regions (IDRs) in the human charged biased proteins identified in our earlier work. We found that 65% of charged biased proteins contained significant IDRs involved particularly in DNA and RNA binding. Also, we have observed that these proteins are well conserved in metazoans and more particularly in mammalian. In addition, the IDRs are located largely in N-terminal, C-terminal sequence flanking the functional domains (FD) and slightly less in (FD) itself. Our work also supports the association between protein disorder and protein–protein/DNA interaction. An example will be described. |
| |
Keywords: | Biased binding charged disorder interaction intrinsic |
|
|