Isolation,Biological Properties,and Spatial Structure of Antibiotic Loloatin A |
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| Authors: | Krachkovskii S A Sobol' A G Ovchinnikova T V Tagaev A A Yakimenko Z A Azizbekyan R R Kuznetsova N I Shamshina T N Arseniev A S |
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| Institution: | (1) Russian Academy of Sciences, Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry, ul. Miklukho-Maklaya 16/10, GSP Moscow, 117997, Russia;(2) Moscow Institute of Physics and Technology, Institutskii per. 9, Dolgoprudnyi, Moscow oblast, 141700, Russia;(3) State Research Institute of Genetics and Selection of Industrial Microorganisms, Pervyi Doroznyi proezd 1, Moscow, 113545, Russia |
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| Abstract: | A peptide antibiotic with cyanolytic activity was isolated from the IGM52 strain of the Brevibacillus laterosporus Gram-positive spore-forming bacteria. By 1H NMR spectroscopy, this antibiotic was identified as loloatin A, a cyclic decapeptide cyclo(-Asn-Asp-Tyr-Val-Orn-Leu-D-Tyr-Pro-Phe-D-Phe-). The spatial structure of loloatin A in solution was determined. |
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| Keywords: | cyclopeptide loloatin NMR peptide antibiotic |
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