Biological and molecular variability of human immunodeficiency virus type 2 isolates from The Gambia. |
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| Authors: | T F Schulz D Whitby J G Hoad T Corrah H Whittle and R A Weiss |
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| Institution: | Chester Beatty Laboratories, Institute of Cancer Research, London, United Kingdom. |
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| Abstract: | Seven new human immunodeficiency virus type 2 (HIV-2) isolates (CBL-20 to CBL-26) from The Gambia were characterized. Their cytopathogenicity and growth in vitro correlated with the severity of clinical disease. CBL-22 was highly sensitive to neutralization by HIV-2 sera and was cross-neutralized by some HIV-1 sera. These findings, the differing sizes of envelope glycoproteins of individual isolates, and the sequence analysis of amplified regions of the viral DNAs show that these HIV-2 isolates from one geographical region in West Africa exhibit biological and genome variability comparable to that observed for HIV-1. |
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