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Study of membranotropic and antioxidant activity of flavonoids and their complexes with ferric iron |
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| Authors: | E. A. Yagolnik Yu. S. Tarahovsky I. B. Klenina S. M. Kuznetsova E. N. Muzafarov Yu. A. Kim |
| Affiliation: | 1. Tula State University, Tula, 300600, Russia 2. Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences, Pushchino, Moscow Region, 142290, Russia 3. Institute of Fundamental Problems of Biology, Russian Academy of Sciences, Pushchino, Moscow Region, 142290, Russia 4. Institute of Cell Biophysics, Russian Academy of Sciences, Pushchino, Moscow Region, 142290, Russia |
| Abstract: | We studied the interaction with liposomes and the antioxidant activity of flavonoid (quercetin, catechin, taxifolin) complexes with iron(III). It was found that the lipophilicity of complexes depends on an iron:flavonoid ratio and grows at a ratio of 1 to 1, while complexes in a 2: 1 ratio were the most effective to slow down the lipid peroxidation and restore radical 2,2-diphenyl-1-picrylhydrazyl. Thus, the stoichiometry of complexes formed in aqueous solution, may differ from the stoichiometry of complexes that most effectively protect membranes from peroxidation. |
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