Age-related Changes in Calbindin-D28k,Parvalbumin, and Calretinin Immunoreactivity in the Dog Main Olfactory Bulb |
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| Authors: | Jung Hoon Choi Choong Hyun Lee Ki-Yeon Yoo In Koo Hwang In Se Lee Yun Lyul Lee Hyung-Cheul Shin Moo-Ho Won |
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| Institution: | (1) Department of Anatomy and Neurobiology, Institute of Neurodegeneration and Neuroregeneration, College of Medicine, Hallym University, Chuncheon, 200-702, South Korea;(2) Department of Anatomy and Cell Biology, College of Veterinary Medicine and BK21 Program for Veterinary Science, Seoul National University, Seoul, 151-742, South Korea;(3) Department of Physiology, College of Medicine, Hallym University, Chuncheon, 200-702, South Korea;(4) Institute of Natural Medicine, Hallym University, Chuncheon, 200-702, South Korea; |
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| Abstract: | Expression and age-related changes of calbindin-D28k (CB), parvalbumin (PV), and calretinin (CR) in the main olfactory bulb
of the dog were investigated by immunohistochemistry and western blot analysis. Neurons that expressed these calcium-binding
proteins showed a characteristic laminar distribution. Most of CB-immunoreactive neurons were observed in the glomerular layer
(GL) and the inner sublayer of the external plexiform layer (EPL). Most of PV-immunoreactive neurons were observed in the
outer sublayer of the EPL. CR-immunoreactive neurons were mainly distributed in the GL and the granule cell layer. With regard
to age-related changes, CB-immunoreactive neurons in the GL were stable among all age groups; however, in the EPL they decreased
with age. PV-immunoreactive neurons decreased in middle-aged and aged groups. However, CR-immunoreactive neurons were not
decreased in middle-aged and aged groups. These results suggest that CB-immunoreactive neurons in the EPL were most sensitive
to aging, and that their reduction may be related to aging in the dog. |
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