| 微生物发酵法生产L-苯丙氨酸的研究进展 |
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| 引用本文： | 周海岩,刘龙,王天文,堵国成,陈坚. 微生物发酵法生产L-苯丙氨酸的研究进展[J]. 工业微生物, 2011, 41(3): 90-98. DOI: 10.3969/j.issn.1001-6678.2011.03.018 |
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| 作者姓名： | 周海岩 刘龙 王天文 堵国成 陈坚 |
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| 作者单位： | 1. 江南大学生物工程学院
2. 江南大学生物工程学院;食品科学与技术国家重点实验室,无锡,214122 |
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| 基金项目： | 973项目,973前期研究专项,国家杰出青年基金项目,国家自然科学基金重点项目,中央高校基本科研业务费专项 |
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| 摘 要： | L-苯丙氨酸 (L-Phe) 是一种重要的必需氨基酸,广泛应用于食品、饲料添加剂以及医药等领域.L-Phe主要由化学合成法、酶法和微生物发酵法等3种方法来生产.其中,微生物发酵法由于具有原料廉价易得、环境污染较小、产物纯度高等优点成为目前国内外工业化生产L-Phe的主要方法.本文主要以大肠杆菌为例对L-Phe生物合成途...
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| 关 键 词： | L-苯丙氨酸 微生物发酵 大肠杆菌 生物合成 代谢调节 |
Recent advances in L-phenylalanine production by microbial fermentation |
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| ZHOU Hai-yan,LIU Long,WANG Tian-wen,DU Guo-cheng,CHEN Jian. Recent advances in L-phenylalanine production by microbial fermentation[J]. Industrial Microbiology, 2011, 41(3): 90-98. DOI: 10.3969/j.issn.1001-6678.2011.03.018 |
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| Authors: | ZHOU Hai-yan LIU Long WANG Tian-wen DU Guo-cheng CHEN Jian |
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| Affiliation: | 1. School of BiotecImology,Jiangnan University, Wuxi 214122, Chitin; 2. State Key laboratory of Food Science and Technology, Jiangnan University, Wuxi 214122, China) |
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| Abstract: | L-phenylalanine （L-Phe） is an important kind ot cssential amino acids.Ii is widely used in the fields of food, feed additives and pharmaceutics. L-Phe can be obtained by chemical, enzymatic or microbial processes. L-Phe production via microbial fermentation is more promising due to its low cost of raw material, less environmental pollution and high purity of product. In this review, Escherichia coli as a main example, the L-Phe biosynthesis pathway and the regulation of key enzymes, strategies of metabolic regulation for enhanced L-Phe biosynthesis, and the key techniques and strategies applied in fermentative production of L-Phe were analyzed and summarized respectively. Based on the understanding of the current challenges, the prospects of L-Phe production by microbial fermentation were proposed |
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| Keywords: | L-phenylalanine microbial fermentation Escherichia coli biosynthesis metabolic regulation |
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