Methods for direct determination of mitomycin C in aqueous solutions and in urine |
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Authors: | Dolores Marín Pedro Pérez Carmen Teijeiro Emil Paleček |
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Institution: | (1) Departamento de Química Física, Universidad de Alcalá, 28871 Alcalá de Henares, Madrid, Spain;(2) Institute of Biophysics, Academy of Sciences of the Czech Republic, Královopolská 135, 61265 Brno, Czech Republic |
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Abstract: | Stripping voltammetry (SV) is used to quantitatively determine concentrations of the anti-neoplastic drug mitomycin C (MMC)
alone and in mixtures with 5-fluorouracil and cisplatin, both of which are used in combined chemotherapy withMMC. If the accumulation
is performed at the potentials of MMC reduction (−0.35Vvs. SCE), reduced MMC is strongly adsorbed at the electrode. It is
possible to prepare a MMCmodified electrode, which, after a washing step, is transferred to the background electrolyte to
determine MMC by voltammetry. This procedure, which is termed transfer stripping voltammetry (TSV), helps to eliminate interferences
and can be applied for a direct determination ofMMCalone or in mixtures with other drugs in urine. |
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