| 分化抑制因子-1在大肠癌中的表达及临床意义 |
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| 引用本文： | 胡斌,陈志康,陈晋湘,葛杰,陈子华.分化抑制因子-1在大肠癌中的表达及临床意义[J].现代生物医学进展,2010,10(1). |
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| 作者姓名： | 胡斌 陈志康 陈晋湘 葛杰 陈子华 |
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| 作者单位： | 中南大学湘雅医院普通外科,湖南,长沙,410008 |
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| 摘 要： | 目的:研究分化抑制因子-1(Id-1)在人大肠癌组织中的表达及其与临床病理特征的关系。方法:应用免疫组织化学方法(SP法)检测Id-1在56例大肠癌组织及56例远癌肠黏膜中的表达水平,并分析其与临床病理特征的关系。结果:在大肠癌组织中Id-1的过表达率为80.4%,在远癌肠粘膜中过表达率为12.5%,两组比较差异有统计学意义(P0.01)。Id-1过表达与大肠癌Dukes分期及淋巴结转移有关(P0.05),而与患者年龄、性别、肿瘤组织分化程度无关(P0.05)。结论:Id-1过表达可能参与大肠癌演进,Id-1可作为判断大肠癌恶性程度和预后的指标。
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| 关 键 词： | 大肠癌 分化抑制因子-1 免疫组织化学 |
The expression and clinical significance of Id-1 in colorectal carcinoma |
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| HU Bin,CHEN Zhi-kang,CHEN jin-xiang,GE Jie,CHEN Zi-hua.The expression and clinical significance of Id-1 in colorectal carcinoma[J].Progress in Modern Biomedicine,2010,10(1). |
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| Authors: | HU Bin CHEN Zhi-kang CHEN jin-xiang GE Jie CHEN Zi-hua |
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| Institution: | HU Bin,CHEN Zhi-kang,CHEN jin-xiang,GE Jie,CHEN Zi-hua(Department of General Surgery,Xiangya Hospital,Central South University,410008,Changsha,China) |
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| Abstract: | Objectives:To study the expression of inhibitor of differentiation/DNA binding(Id-1) in human colorectal carcinoma and its relation to clinicopathological characteristics.Methods:The expression of Id-1 in 56 cases of colorectal carcinoma and 56 cases of intestinal mucosa distant from the tumor were determined by immunohistochemical method(SP method),and the relationship between the expression of Id-1 and the clinicopathological characteristics were analyzed.Results:The overexpression rates of Id-1 in colore... |
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| Keywords: | colorectal carcinoma Id-1 immunohistochemistry |
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