Studies on flavone in the guinea pig |
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| Authors: | N. P. Das and L. A. Griffiths |
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| Affiliation: | Department of Biochemistry, Faculty of Medicine, University of Singapore, Singapore 3;Department of Physiological Chemistry, University of Birmingham |
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| Abstract: | 1. The metabolism of flavone has been studied in the guinea pig; after administration of the compound either orally or intraperitoneally, 4'-hydroxyflavone is excreted in the urine. 2. Small amounts of 3',4'-dihydroxyflavone were also detected in the urine after oral administration of flavone. 3. Hydroxyflavone formation is not suppressed by administering high doses of the antibacterial compounds aureomycin and phthaloylsulphathiazole. 4. Although salicylic acid appeared in trace quantities in the urine after administration of flavone, no other aromatic acid metabolites of flavone were detected. |
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