Spatial Structure of BAM-12P Dodecapeptide and Its Analogues |
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| Authors: | Email author" target="_blank">N?A?AkhmedovEmail author Z?H?Tagiev E?M?Hasanov T?A?Makhmudova |
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| Institution: | (1) Baku State University, Z. Khalilov 23, Baku, AZ-1073/1, Azerbaijan;(2) Azerbaijan Medical University, Bakikhanov 23, Baku, 370022, Azerbaijan |
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| Abstract: | Theoretical conformational analysis was used to study the spatial structure and conformational properties of the bovine adrenal medulla dodecapeptide BAM-12P (Tyr1-Gly2-Gly3-Phe4-Met5-Arg6-Arg7-Val8-Gly9-Arg10-Pro11-Glu12). Twenty-three low-energy conformations of the BAM-12P backbone were shown to represent the spatial structure of the peptide. The inverse structural problem was solved, and synthetic analogues of BAM-12P were proposed, the spatial structures of which correspond to a set of low-energy potentially physiologically active conformations of the natural dodecapeptide.__________Translated from Bioorganicheskaya Khimiya, Vol. 31, No. 3, 2005, pp. 245–250.Original Russian Text Copyright © 2005 by Akhmedov, Tagiev, Hasanov, Makhmudova. |
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| Keywords: | BAM-12P structure and function theoretical conformational analysis |
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