N(4)-amino-and N(4)-hydroxycytosines as base analogue mutagens |
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Authors: | B C Chu D M Brown M G Burdon |
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Institution: | 1. University Chemical Laboratory, Cambridge, UK;1. Department of Molecular Biology, University of Edinburgh, Edinburgh, Great Britain |
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Abstract: | N(4)-Aminocytosine N(4)NH2C] and N(4)-amino-2′-deoxycytidine N(4)NH2dC] are highly mutagenic for Escherichia coli and phage φ 80 but not for T4. There is some evidence that they are incorporated into the φ 80 DNA but could not be detected in the bacterial DNA.N(4)-Hydroxy-5,6-dihydro-6-hydroxylaminodeoxycytidine (di-NHOH-dC) is mutagenic for φ 80 and E. coli, but N(4)-hydroxydeoxycytidine N(4)OH-dC] only has a strong inactivating effect. |
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Keywords: | 2AP 2-aminopurine 5BdU 5-bromodeoxyuridine dC deoxycytidine di-NHOH-dC 5FU 5-fluorouracil HA hydroxylamine HZ hydrazine 4-thiodeoxyuridine |
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