输血后乙型肝炎的研究

对204例首次受血(1～2单位)的外科手术患者进行了随访,以观察输血后HBV的感染和发病。血源来自224例HBsAg阴性(RPHA法检测)的献血员,受血者于受血前及受血后6～7个月各采血1次,连同献血员献血前的血清,用同一批RIA试剂检测HBsAg、抗-HBs和抗-HBc。发现用RPHA筛选的HBsAg阴性献血员,用RIA检测时,仍有2.2％(5/224)HBsAg阳性。70例HBV易感者中,受血后13例发生HBV感染,其中2例输入HBsAg阳性血液者发生急性肝炎(2.86％),1例为黄疸型乙型肝炎,另一例为NANB肝炎;11例发生HBV感染,其中8例为输入HBV-DNA阳性血液。以上结果表明,RPHA筛选献血员仍不能杜绝输血后肝炎,RIA筛选献血员后不能杜绝亚临床感染。部分HBV感染不能排除医院内感染的可能性。

THE STUDY ON POST-TRANSFUSION HEPATITIS

Two hundred and four cases of surgical gynecological patients have received, for the first time, 1-2 units of "HBsAg negative" blood,screened by RPHA, in 4 county hospitals. In all the recipients blood samples were collected just before and 6-7 months after the transfusion and all of the blood samples of donors attached to blood container tested by one lot of RIA kit, at one time, for serologic HBsAg anti-HBs and anti-HBc. The results showed that 5 of the 224 donors ( 2.2%) were HBsAg positive when retested by RIA. Two of the 70 HBV-susceptible recipients have suffered from clinic acute hepatitis 2-3 months after transfusion,one of whom was NANB hepatitis and another was hepatitis B cases.A total of 13 HBV susceptible recipients were infected by HBV, two of whom received both HBsAg and HBV-DNA positive blood,one resulted in clinical hepatitis B and another one subclinical HBV infection,and the remaining 11 cases showed subclinic HBV infection, 8 of whom received HBV-DNA positive blood (see table 3. )The results indicated that the RPHA-screened blood was still dangerous in the infection with post-transfusion hepatitis.