Complete genome sequencing and comparative analysis of the linezolid-resistant Enterococcus faecalis strain DENG1 |
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| Authors: | Zhijian Yu Zhong Chen Hang Cheng Jinxin Zheng Duoyun Li Xiangbin Deng Weiguang Pan Weizhi Yang Qiwen Deng |
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| Affiliation: | 1. Shenzhen Key Lab for Endogenous Infection, Department of Infectious Diseases, The Affiliated Shenzhen Nanshan Hospital, Guangdong Medical College, No 89, Taoyuan Road, Nanshan district, Shenzhen, 518052, China
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| Abstract: | Genome level analysis of bacterial strains provides information on genetic composition and resistance mechanisms to clinically relevant antibiotics. To date, whole genome characterization of linezolid-resistant Enterococcus faecalis isolated in the clinic is lacking. In this study, we report the entire genome sequence, genomic characteristics and virulence factors of a pathogenic E. faecalis strain, DENG1. Our results showed considerable differences in genomic characteristics and virulence factors compared with other E. faecalis strains (V583 and OG1RF). The genome of this LZD-resistant E. faecalis strain can be used as a reference to study the mechanism of LZD resistance and the phylogenetic relationship of E. faecalis strains worldwide. |
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