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The Relationship Between Selenium Levels and Breast Cancer: A Systematic Review and Meta-Analysis |
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| Authors: | Nasim Babaknejad Fatemeh Sayehmiri Kourosh Sayehmiri Parya Rahimifar Somaye Bahrami Ali Delpesheh Farhad Hemati Sajjad Alizadeh |
| Affiliation: | 1. Msc Biochemistry, Department of Medical Microbiology, School of Medicine, Ilam University of Medical Sciences, Ilam, Iran 2. Department of Social Medicine, School of Medicine, Ilam University of Medical Sciences, Ilam, Iran 3. Psychosocial Injuries Research Center, Ilam University of Medical Sciences, Ilam, Iran 5. School of Medicine, Ilam University of Medical Sciences, Ilam, Iran 4. Msc Biochemistry, Students Research Committee, Ilam University of Medical Sciences, Ilam, Iran |
| Abstract: | Breast cancer is the most common cancer type. In several studies, hints have been provided that there is a correlation between selenium deficiency and the incidence of breast cancer. Findings of these published reports are, however, inconsistent. This study serves as a pioneering study aiming at combining the results of studies using a meta-analytic method. A total of 16 articles published between 1980 and 2012 worldwide were selected through searching PubMed, Scopus, and Google scholar databases, and the information were analyzed using a meta-analytic method [random effects model]. I 2 statistics were used to examine heterogeneity. The information was then analyzed by STATA version 12. In this study, due to the non-uniform methods used to measure selenium concentrations, selenium levels were measured in the various subgroups in both case and control groups. There were significant correlations between selenium concentration and breast cancer [P? |
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