In vitro culture of fibroblasts from pubic skin of women in diagnosis of androgen hypersensitivity] |
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Authors: | S Wo?czyński W Kuczyński M Kulikowski M Szamatowicz |
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Affiliation: | Zak?ad Endokrynologicznej Ginekologicznej AM w Bia?ymstoku. |
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Abstract: | Intracellular metabolism of testosterone was studied in in vitro cultured skin fibroblasts obtained from women with idiopathic hirsutism. A significantly higher rate of conversion of testosterone into 5-alpha-dihydrotestosterone was found in these women (4.78 +/- 2.08 fmol/microgram DNA/hour) as compared to that obtained for skin cultures of women without symptoms of androgenization (0.98 +/- 0.37 fmol/microgram DNA/hour). These results demonstrate that fibroblast culture may be useful in diagnosing the causes of hyperandrogenization in women with normal androgen secretion. |
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