Synthesis and in vitro trypanocide activity of several polycyclic drimane-quinone derivatives |
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| Authors: | Cuellar Mauricio A Salas Cristian Cortés Manuel J Morello Antonio Diego Maya Juan Preite Marcelo D |
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| Affiliation: | Departamento de Química Orgánica, Facultad de Química, Pontificia Universidad Católica de Chile, Vicu?a Mackenna 4860, Casilla 306, Correo 22, Santiago, Chile. |
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| Abstract: | The Diels-Alder reaction between two polygodial-derived dienes and simple quinones to yield substituted naphtho- and anthraquinones, is described. The in vitro trypanocide activity for the series was determined. Two of the new compounds showed an activity ten and two times higher, respectively, than nifurtimox and benznidazole, the medicines of choice for the treatment of the acute Chagas' disease. |
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