Norbornyllactone-substituted xanthines as adenosine A(1) receptor antagonists |
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| Authors: | Kiesman William F Zhao Jin Conlon Patrick R Petter Russell C Jin Xiaowei Smits Glenn Lutterodt Frank Sullivan Gail W Linden Joel |
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| Institution: | Department of Medicinal Chemistry, Biogen Idec, Inc., 14 Cambridge Center, Cambridge, MA 02142, USA. william.kiesman@biogenidec.com |
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| Abstract: | During the search for second-generation adenosine A(1) receptor antagonist alternatives to the clinical candidate 8-(3-oxa-tricyclo3.2.1.0(2,4)]oct-6-yl)-1,3-dipropyl-3,7-dihydro-purine-2,6-dione (BG9719), we developed a series of novel xanthines substituted with norbornyl-lactones that possessed high binding affinities for adenosine A(1) receptors and in vivo activity. |
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