Oxidative DNA cleavage induced by an iron(III) flavonoid complex: synthesis, crystal structure and characterization of chlorobis(flavonolato)(methanol) iron(III) complex |
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Authors: | El Amrani Fátima Ben Allal Perelló Lourdes Real Jose A González-Alvarez Marta Alzuet Gloria Borrás Joaquín García-Granda Santiago Montejo-Bernardo José |
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Institution: | Departament de Química Inorgànica, Universitat de València, Avda. Vicent Andrés Estellés s/n, 46100 Burjassot, Spain. |
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Abstract: | A flavonol iron(III) complex, Fe(flavonolato)(2)Cl(MeOH)], has been prepared. The compound has been characterized by X-ray crystallography, spectroscopy, magnetism and electronic paramagnetic resonance (EPR) at X- and Q-band. The geometrical environment around the metal is best described as rhombic distorted octahedral. This distortion has also been inferred from the magnetic measurements and from the EPR spectra at different temperatures, E/D(rhombicity parameter) approximately 0.06. The DNA cleavage activity of the iron(III) complex with and without ascorbate/hydrogen peroxide is reported. Mechanisms of the oxidative cleavage have been proposed when DNA strand scission is performed both with and without ascorbate/hydrogen peroxide activation. |
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