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Novel method for early signs of clinical shock detection by monitoring blood capillary/vessel spatial pattern |
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| Authors: | Rajesh Kanawade Florian Klämpfl Max Riemann Christian Knipfer Katja Tangermann‐Gerk Michael Schmidt Florian Stelzle |
| Affiliation: | 1. Clinical Photonics Lab., Erlangen Graduate School in Advanced Optical Technologies SAOT, Friedrich‐Alexander‐Universit?t Erlangen‐Nürnberg, Paul‐Gordan‐Stra?e 6, 91052 Erlangen, Germany;2. Institute of Photonic Technologies, Friedrich‐Alexander‐Universit?t Erlangen‐Nürnberg, Paul‐Gordan‐Stra?e 3, 91052 Erlangen, Germany;3. Department of Oral and Maxillofacial Surgery, University Hospital Erlangen, Friedrich‐Alexander‐Universit?t Erlangen‐Nürnberg, Glück‐Stra?e 11, 91054 Erlangen, Germany;4. Bayerisches Laserzentrum GmbH, Konrad‐Zuse‐Stra?e 2–6, 91052 Erlangen, Germany |
| Abstract: | The ability to monitor capillary/vessel spatial patterns and local blood volume fractions is critical in clinical shock detection and its prevention in Intensive Care Units (ICU). Although the causes of shock might be different, the basic abnormalities in pathophysiological changes are the same. To detect these changes, we have developed a novel method based on both spectrally and spatially resolved diffuse reflectance spectra. The preliminary study has shown that this method can monitor the spatial distribution of capillary/vessel spatial patterns through local blood volume fractions of reduced hemoglobin and oxyhemoglobin. This method can be used as a real‐time and non‐invasive tool for the monitoring of shock development and feedback on the therapeutic intervention. (© 2014 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim) |
| Keywords: | Clinical shock reduced hemoglobin (RHb) oxyhemoglobin (HbO2) oxygen saturation (SO2) epithelium capillary/vessel spatial pattern spatially resolved diffuse reflectance skin tissue phantom |