Structure of the poly(2-thiouridylic) acid duplex |
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| Authors: | Struther Arnott R. Chandrasekaran A.G.W. Leslie L.C. Puigjaner W. Saenger |
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| Affiliation: | Department of Biological Sciences Purdue University, West Lafayette, Ind. 47907, U.S.A. |
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| Abstract: | The crystal and molecular structures of poly(2-thiouridylic) acid are remarkably similar to those of A-DNA. How this might be contrived with homopolymer duplexes containing either symmetric or asymmetric pyrimidine pyrimidine base-pairs is described using molecular models optimized by the linked-atom least-squares method. This study supplements an earlier manual model-building study of the second possibility by Mazumdar et al. (1974). |
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