Chromatin remodeling and Rb activity |
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Authors: | Harbour J W Dean D C |
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Institution: | Division of Molecular Oncology, Washington University, St Louis, Missouri 63110, USA. |
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Abstract: | Progression of cells through the cell cycle is central to normal cell proliferation, and checkpoints that regulate this cycle are targets of tumorigenic mutations. One of these checkpoints is the Rb family of proteins that seems to regulate exit of cells from both G(1) and S phase of the cell cycle. Recent studies have linked the function of the Rb family to chromatin remodeling enzymes. |
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