| A case of hepatitis B reactivation in an anti-HBs positive, anti-HBc positive non-Hodgkin’s lymphoma patient |
| |
| 基金项目： | the National Basic Research Priorities Program of China，National Natural Science Foundation of China，the Fundamental Research Funds for the Central Universities |
| |
| 摘 要： | Dear Editor,
We report a case of HBV reactivation in an anti-HBs positive,anti-HBc positive non-Hodgkin's lymphoma patient.Hepatitis B virus (HBV) reactivation is a well-recognized complication of patients undergoing chemotherapy or immunosuppressive therapy for lymphomas.The presence of antibodies to the hepatitis B surface antigen (anti-HBs) has been identified to be a factor preventing HBV reactivation in patients with occult HBV infection receiving chemotherapy.In this paper,we present a non-Hodgkin Lymphoma patient who,before immunosuppressive therapy,displayed positive anti-HBs and positive antibodies to hepatitis B core antigens (anti-HBc),as markers of resolved HBV infection,and developed hepatitis B surface antigen (HBsAg) and high viraemia with an HBV escape mutant after rituximabbased administration.The sequencing data revealed HBV genotype D with two known escape mutations,P120S.
|
| 收稿时间： | 2012 Sep 11 |
A Case of Hepatitis B Reactivation in an Anti-HBs Positive,Anti-HBc Positive non-Hodgkins Lymphoma Patient |
| |
| Authors: | Chunchen Wu Hui Shi Mengji Lu Yang Xu Xinwen Chen |
| |
| Institution: | 1.State Key Lab of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan 430071, China2.Department of Microbiology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China3.Institute of Virology, University Hospital of Essen, Essen D45122, Germany |
| |
| Abstract: | Dear Editor,
We report a case of HBV reactivation in an anti-HBs positive,anti-HBc positive non-Hodgkin's lymphoma patient.Hepatitis B virus (HBV) reactivation is a well-recognized complication of patients undergoing chemotherapy or immunosuppressive therapy for lymphomas.The presence of antibodies to the hepatitis B surface antigen (anti-HBs) has been identified to be a factor preventing HBV reactivation in patients with occult HBV infection receiving chemotherapy.In this paper,we present a non-Hodgkin Lymphoma patient who,before immunosuppressive therapy,displayed positive anti-HBs and positive antibodies to hepatitis B core antigens (anti-HBc),as markers of resolved HBV infection,and developed hepatitis B surface antigen (HBsAg) and high viraemia with an HBV escape mutant after rituximabbased administration.The sequencing data revealed HBV genotype D with two known escape mutations,P120S. |
| |
| Keywords: | Lymphoma Patient Virus Reactivation Escape Mutant Virus Escape Mutant |
| 本文献已被 万方数据 SpringerLink 等数据库收录！ |
| 点击此处可从《中国病毒学》浏览原始摘要信息 |
| 点击此处可从《中国病毒学》下载免费的PDF全文 |
|
