Maternal transmission of type D simian retrovirus (SRV-2) in pigtailed macaques |
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| Authors: | C C Tsai K E Follis K Snyder S Windsor M E Thouless L Kuller W R Morton |
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| Affiliation: | Regional Primate Research Center, University of Washington, Seattle. |
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| Abstract: | Pregnant macaques were used as a natural model for maternal-infant transmission of SRV-2 retrovirus. Fifty-one pregnant females were placed into one of four virus/antibody groups. Nonviremic mothers produced 100% virus-negative offspring at birth. In contrast, viremic mothers produced offspring which were 17% virus-negative and 83% virus-positive at birth. SRV-2 infection occurred principally in utero by the transplacental route. Infants born to viremic mothers exhibited low birth weight, prematurity, high perinatal death, and increased incidence of SAIDS. |
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| Keywords: | Simian AIDS Type D simian retrovirus |
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