Inhibition of proinsulin biosynthesis and conversion by a putative insulin mediator |
| |
Authors: | J Camara A Albor J M Mato W J Malaisse I Valverde |
| |
Institution: | Fundacion Jimenez Diaz and Consejo Superior de Investigaciones Cientificas, Madrid, Spain. |
| |
Abstract: | The phospho-oligosaccharide (POS), presumed to act at the postreceptor level as the insulin second messenger, was recently reported to inhibit glucose-stimulated insulin release from rat pancreatic islets. In the present study, POS was also found to inhibit glucose-stimulated proinsulin biosynthesis and conversion in rat islets. By comparison with prior findings on the effects of both exogenous insulin and anti-insulin serum upon proinsulin synthesis, these results argue against the view that insulin would normally exert a negative feedback control upon the biosynthetic and secretory activities of islet B-cells. |
| |
Keywords: | |
|
|