A new ecdysteroid and other constituents from two Dioscorea species |
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| Authors: | M. Sautour F. Canon T. Miyamoto A. Dongmo M.-A. Lacaille-Dubois |
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| Affiliation: | aLaboratoire de Pharmacognosie, Unité de Molécules d'Intérêt Biologique, UMIB UPRES-EA 3660, Faculté de Pharmacie, Université de Bourgogne, 7, Bd. Jeanne d'Arc, BP 87900, 21079 Dijon Cedex, France;bGraduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka, Japan;cLaboratoire de Biologie des Organismes Animaux, Faculté des Sciences, Université de Douala, Cameroon |
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| Abstract: | Phytochemical investigation of the rhizome of Dioscorea dumetorum has led to the isolation by several chromatographic steps on normal and reversed phase silica gel of a new ecdysteroid, (20R)-5β,11α,20-trihydroxyecdysone (1), and two known ecdysteroids, ajugasterone C (2) and herkesterone (3). Their structures were determined by spectroscopic methods including 1D- and 2D-NMR (COSY, TOCSY, HSQC and HMBC). This is the first report on the occurrence of phytoecdysteroids in the Dioscoreaceae family. These compounds were devoid of antifungal activity against three Candida species (Candida albicans, Candida glabrata and Candida tropicalis, MIC > 200 μg/ml). |
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| Keywords: | Dioscorea dumetorum Dioscorea schimperiana Dioscoreaceae Ecdysteroids 2D-NMR |
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