Amplification of the action of subthreshold doses of aldosterone by 19-hydroxyandrost-4-ene-3, 17-dione. |
| |
Authors: | H Sekihara N Ohsawa K Kosaka |
| |
Institution: | Department of Biochemistry University of California Riverside, California 92521 USA |
| |
Abstract: | Various 1α-hydroxylated side chain analogs of vitamin D3 have been studied for their ability to compete with 1α,25-dihydroxy3H]vitamin D3 for binding to the chick intestinal receptor. Of the analogs examined, 1α,24R-dihydroxyvitamin D3 was found to be nearly equivalent to 1α,25-dihydroxyvitamin D3 in its ability to compete for receptor binding. However, this near equivalence was not shared by its stereoisomer, 1α,24S-dihydroxyvitamin D3, which was only 10% as effective a competitor. It is proposed that the ability of a 24R-hydroxyl group to mimic the 25-hydroxyl group is not due to a lack of side chain specificity on the part of the receptor, but is instead due to the similar orientation of the 25-hydroxyl and the 24R-hydroxyl such that they can be accommodated equivalently by the receptor. |
| |
Keywords: | To whom all inquires should be made |
本文献已被 ScienceDirect 等数据库收录! |
|