Polyketides from Mantis‐Associated Fungus Daldinia eschscholzii IFB‐TL01 |
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| Authors: | Gang Wang Jing‐Yang Fan Wen‐Jing Zhang Cheng‐Pin Hua Chao‐Jun Chen Wei Yan Hui‐Ming Ge Rui‐Hua Jiao Ren‐Xiang Tan |
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| Institution: | Institute of Functional Biomolecules, State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing 210093, P.?R. China (phone/fax: +86‐25‐83593201) |
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| Abstract: | Three new polyketides, named daldinone F ( 1 ), nodulisporin G ( 2 ), and dalmanol C ( 3 ), together with five known compounds, 4 – 8 , were isolated from cultures of Daldinia eschscholzii. The structures of the new compounds were elucidated by extensive NMR and MS analyses. Compound 1 showed moderate cytotoxic activity against SW480 cancer cells with an IC50 value of 9.59 μM , and its absolute configuration was determined by single crystal X‐ray diffraction. |
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| Keywords: | Cytotoxic activity Daldinia eschscholzii Polyketides Radical coupling |
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