Four New Flavonoids with α‐Glucosidase Inhibitory Activities from Morus alba var. tatarica |
| |
| Authors: | Ya‐Long Zhang Jian‐Guang Luo Chuan‐Xing Wan Zhong‐Bo Zhou Ling‐Yi Kong |
| |
| Affiliation: | 1. State Key Laboratory of Natural Medicines, Department of Natural Medicinal Chemistry, China Pharmaceutical University, 24 Tong Jia Xiang, Nanjing 210009, P.?R. China, (phone/fax: +86‐25‐83271405);2. Key Laboratory of Protection and Utilization of Biological Resources in Tarim Basin of Xinjiang Production & Construction Group, Tarim University, Alaer 843300, P.?R. China |
| |
| Abstract: | Four new flavonoids, mortatarins A–D ( 1 – 4 , resp.), along with eight known flavonoids ( 5 – 12 ) were isolated from the root bark of Morus alba var. tatarica. Their structures were established on the basis of spectroscopic data analysis, and the absolute configuration of 4 was determined by analysis of its CD spectrum. All isolates were tested for inhibitory activities against α‐glucosidase. Compounds 4, 7 , and 8 exhibited a significant degree of inhibition with IC50 values of 5.0±0.3, 7.5±0.5, and 5.9±0.2 μM , respectively. |
| |
| Keywords: | Morus alba Flavonoids α ‐Glucosidase Mortatarins A – D |
|
|
