Lupane‐ and Friedelane‐Type Triterpenoids from Celastrus stylosus |
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| Authors: | You‐Min Ying Cui‐Yu Li Yan Chen Jia‐Gui Xiang Ling Fang Jian‐Biao Yao Fa‐Song Wang Ru‐Wei Wang Wei‐Guang Shan Zha‐Jun Zhan |
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| Institution: | 1. College of Pharmaceutical Science, Zhejiang University of Technology, Hangzhou 310014, P.?R. China, (phone/fax: +86‐571‐88871075 (Z.‐J. Zhan), +86‐571‐88320554 (W.‐G. Shan);2. , (Z.‐J. Zhan), (W.‐G. Shan));3. Zhejiang Key Laboratory of Traditional Chinese Medicine Pharmaceutical Technology, Zhejiang CONBA Pharmaceutical Co., Ltd., Hangzhou 310052, P.?R. China;4. Key Laboratory of Biologic Resources Protection and Utilization of Hubei Province and College of Chemistry and Environmental Engineering, Hubei University for Nationalities, Enshi 445000, P.?R. China |
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| Abstract: | Two new triterpenoids, 30‐hydroxylup‐20(29)‐ene 3β‐caffeate ( 1 ) and 24‐nor‐friedelan‐6α,10‐dihydroxy‐1,2‐dioxo‐4,7‐dien‐29‐oic acid ( 2 ), together with eight known compounds 3 – 10 , were isolated from the roots of Celastrus stylosus. The structures of these compounds were elucidated on the basis of spectroscopic analyses. To the best of our knowledge, this represents the first study on the chemical constituents of C. stylosus. The antiproliferative activities of the triterpenoids against six human cancer cell lines (PANC‐1, A549, PC‐3, HepG2, SGC‐7901, and HCCLM3) were evaluated. Compounds 3, 4 , and 10 exhibited comparable activities against PC‐3 and HCCLM3 cell lines as the positive control taxol. |
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| Keywords: | Celastrus stylosus Triterpenoids Antiproliferative activities Friedelanes Lupanes |
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