Merosesquiterpenoids and Ten‐Membered Macrolides from a Soft Coral‐Derived Lophiostoma sp. Fungus |
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| Authors: | Cai‐Juan Zheng Chang‐Lun Shao Min Chen Zhi‐Gang Niu Dong‐Lin Zhao Chang‐Yun Wang |
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| Institution: | 1. Key Laboratory of Marine Drugs, The Ministry of Education of China, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, P.?R. China;2. Key Laboratory of Tropical Medicinal Plant Chemistry of Ministry of Education, College of Chemistry and Chemical Engineering, Hainan Normal University, Haikou 571158, P.?R. China, (phone: +86‐532‐82031536;3. fax: +86‐532‐82031536 ext. 266003) |
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| Abstract: | One new merosesquiterpenoid, craterellin D ( 1 ), along with one known analog, craterellin A ( 2 ), and five known ten‐membered macrolides, 3 – 7 , were isolated from a soft coral‐derived Lophiostoma sp. fungus. The absolute configuration of 1 was established based on biogenetic consideration with the co‐isolated analog 2 , whose configuration was determined by modified Mosher's method and single‐crystal X‐ray diffraction analysis using CuKα radiation. The absolute configuration of 3 was determined by X‐ray diffraction analysis using CuKα radiation. Compounds 2 and 3 showed antibacterial activities against Bacillus cereus with a MIC value of 3.12 μM . |
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| Keywords: | Antibacterial activity Lophiostoma Macrolides Merosesquiterpenoids |
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