Three New Isomeric Indole Alkaloids from Nauclea officinalis |
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| Authors: | Hai‐Yang Wang Ru‐Xia Wang Yan‐Xia Zhao Ke Liu Feng‐Ling Wang Jing‐Yong Sun |
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| Institution: | 1. Key Laboratory of Rare and Uncommon Diseases, Institute of Materia Medica, Shandong Academy of Medical Sciences, Ji'nan, 250062, Shandong, P.?R. China, (phone: +86‐531‐82919963;2. fax: +86‐531‐82919963);3. Shandong Academy of Medical Sciences Graduate Education Center, Ji'nan, 250062, Shandong, P.?R. China;4. Suzhou Reina Pharmaceutical R & D Co., Ltd., Suzhou, 215123, Jiangsu, P.?R. China |
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| Abstract: | Three new isomeric monoterpene indole alkaloids, naucleofficines I–III ( 1 – 3 , resp.) were isolated from the stems (with bark) of Nauclea officinalis. Their structures were elucidated on the basis of spectroscopic methods and single‐crystal diffraction analyses. The cytotoxic activities of 1 – 3 against human colon cancer, human gastric cancer, and human hepatoma cells were also investigated. |
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| Keywords: | Monoterpene indole alkaloids Naucleofficines I – III Nauclea officinalis Cytotoxic activity |
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