Two New Hydronaphthoquinones from Sinningia aggregata (Gesneriaceae) and Cytotoxic Activity of Aggregatin D |
| |
| Authors: | Maria Helena Verdan Lauro Mera de Souza João Ernesto de Carvalho Débora B Vendramini Costa Marcos José Salvador Andersson Barison Maria Élida Alves Stefanello |
| |
| Institution: | 1. Department of Chemistry, Federal University of Paraná, Curitiba, PR, 81531‐980, Brazil, (phone: +55‐41‐33613177;2. fax: +55‐41‐33613186);3. Department of Biochemistry and Molecular Biology, Federal University of Paraná, Curitiba, PR, 81531‐980, Brazil;4. CPQBA‐UNICAMP, State University of Campinas, Campinas, SP, 13083‐970, Brazil;5. Department of Plant Biology, Institute of Biology/Faculty of Pharmaceutical Sciences, PPG‐BTPB, University of Campinas, Campinas, SP, 13083‐970, Brazil |
| |
| Abstract: | Two new hydronaphthoquinones, aggregatins E and F ( 1 and 2 , resp.) were isolated from the tubers of Sinningia aggregata (Ker‐Gawl .) Wiehler (Gesneriaceae), along with twelve known compounds aggregatin D ( 3 ), tectoquinone ( 4 ), 1‐hydroxy‐2‐methylanthraquinone ( 5 ), icosyl ferulate ( 6 ), pustuline ( 7 ), 1,6‐dihydroxy‐2‐methylanthranquinone ( 8 ), 6‐hydroxy‐2‐methylanthraquinone ( 9 ), 7‐hydroxy‐2‐methylanthraquinone ( 10 ), tyrosol ( 11 ), halleridone ( 12 ), calceolarioside B ( 13 ), and cornoside ( 14 ). All compounds were identified by analysis of spectroscopic and spectrometric data. Compounds 3, 4 , and 10 had already been reported in this species. Compounds 2 and 3 were evaluated against several tumor cell lines, but only 3 exhibited activities against UACC‐62, 786‐0 and OVCAR‐3 cell lines, with IC50 values of 12.3, 12.8 and 0.3 μg/ml, respectively, without toxic effects on non‐cancer cell line HaCat (human keratinocyte). |
| |
| Keywords: | Sinningia aggregata Naphthoquinones Anthraquinones Cytotoxic activity |
|
|
