Secondary Metabolites from Aspergillus fumigatus,an Endophytic Fungus from the Liverwort Heteroscyphus tener (Steph.) Schiffn. |
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| Authors: | Fei Xie Xiao‐Bin Li Jin‐Chuan Zhou Qing‐Qing Xu Xiao‐Ning Wang Hui‐Qing Yuan Hong‐Xiang Lou |
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| Institution: | 1. Department of Natural Products Chemistry, Key Lab of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Shandong University, No.?44 West Wenhua Road, Jinan 250012, P.?R. China (phone: +86‐531‐88382012;2. fax: +86‐531‐88382548);3. Department of Biochemistry and Molecular Biology, School of Medicine, Shandong University, No.?44 West Wenhua Road, Jinan 250012, P.?R. China;4. fax: +86‐531‐88382548)Department of Natural Products Chemistry, Key Lab of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Shandong University, No.?44 West Wenhua Road, Jinan 250012, P.?R. China (phone: +86‐531‐88382012 |
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| Abstract: | Three new metabolites, asperfumigatin ( 1 ), isochaetominine ( 10 ), and 8′‐O‐methylasterric acid ( 21 ), together with nineteen known compounds, were obtained from the culture of Aspergillus fumigatus, an endophytic fungus from the Chinese liverwort Heteroscyphus tener (Steph.) Schiffn. Their structures were established by extensive analysis of the spectroscopic data. The absolute configurations of 1 and 10 were determined by analysis of their respective CD spectra. Cytotoxicity of these isolates against four human cancer cell lines was also determined. |
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| Keywords: | Aspergillus fumigatus Metabolites Asperfumigatin Isochaetominine Asterric acid 8′ ‐O‐methyl‐ Cytotoxic activity |
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