Cyclic dipeptides from lactic acid bacteria inhibit proliferation of the influenza a virus |
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Authors: | Min-Kyu Kwak Rui Liu Jun-Oh Kwon Min-Kyu Kim Andrew HyoungJin Kim Sa-Ouk Kang |
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Institution: | 1. Laboratory of Biophysics, School of Biological Sciences, and Institute of Microbiology, Seoul National University, Seoul, 151-747, Republic of Korea
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Abstract: | We isolated Lactobacillus plantarum LBP-K10 from the traditional Korean fermented food kimchi. When organic acids were removed, the culture filtrate of this isolate showed high antiviral activity (measured using a plaque-forming assay) against the influenza A (H3N2) virus. Two fractions that were active against influenza A virus were purified from the culture filtrate using a C18 column with high-performance liquid chromatography. These active fractions were crystallized and identified to be the cyclic dipeptides cis-cyclo (l-Leu-l-Pro) and cis-cyclo(l-Phe-l-Pro) using gas chromatography-mass spectrometry; this identification was confirmed by X-ray crystallography. These cyclic dipeptides were identified in the culture filtrate of other lactic acid bacteria, including Lactobacillus spp., Leuconostoc spp., Weissella spp., and Lactococcus lactis. |
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