Synthesis and evaluation of imidazo[1,5-a]pyrazines as corticotropin releasing hormone receptor ligands |
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| Authors: | Hartz Richard A Gilligan Paul J Nanda Kausik K Tebben Andrew J Fitzgerald Larry W Miller Keith |
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| Institution: | DuPont Pharmaceuticals Company, Chemical and Physical Sciences, Experimental Station, PO Box 80500, 19880, Wilmington, DE 19880, USA. richard.a.hartz@dupontpharm.com |
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| Abstract: | A novel series of imidazo1,5-a]pyrazines was synthesized and evaluated as corticotropin releasing hormone (CRH) receptor ligands. SAR studies focused primarily on dialkylamino side chain optimization. SAR of the aryl and small alkyl substituents was also explored. |
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