Cathepsin D stimulates DNA synthesis and mitosis in mouse liver in vivo |
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| Authors: | M Morioka H Terayama |
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| Affiliation: | Zoological Institute, Faculty of Science, University of Tokyo, Hongo, Tokyo 113, Japan |
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| Abstract: | Effects of a single intraperitoneal injection of cathepsin D (CatD) on DNA synthesis and mitosis in the mouse liver and kidney were investigated. Twenty micrograms of catD induced a significant stimulation of DNA synthesis in the liver, but not in the kidney, in a dose-dependent fashion and with a peak activity at 38 h after the injection. CatD also stimulated liver mitosis, with a peak value at 44 h after the injection. |
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