RAIphy: Phylogenetic classification of metagenomics samples using iterative refinement of relative abundance index profiles |
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| Authors: | Ozkan U Nalbantoglu Samuel F Way Steven H Hinrichs Khalid Sayood |
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| Institution: | (1) Department of Electrical Engineering, 209N WSEC University of Nebraska-Lincoln, 68588-0511 Lincoln, NE, USA;(2) Department of Pathology and Microbiology, University of Nebraska Medical Center, 68198 Omaha, NE, USA |
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| Abstract: | Background Computational analysis of metagenomes requires the taxonomical assignment of the genome contigs assembled from DNA reads of
environmental samples. Because of the diverse nature of microbiomes, the length of the assemblies obtained can vary between
a few hundred bp to a few hundred Kbp. Current taxonomic classification algorithms provide accurate classification for long
contigs or for short fragments from organisms that have close relatives with annotated genomes. These are significant limitations
for metagenome analysis because of the complexity of microbiomes and the paucity of existing annotated genomes. |
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