Depletion of the histone chaperone tNASP inhibits proliferation and induces apoptosis in prostate cancer PC-3 cells |
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| Authors: | Oleg M Alekseev Richard T Richardson James K Tsuruta Michael G O'Rand |
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| Institution: | (1) Department of Cell and Developmental Biology, University of North Carolina, Chapel Hill, NC 27599, USA;(2) Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC 27599, USA;(3) Laboratories for Reproductive Biology, University of North Carolina, Chapel Hill, NC 27599, USA |
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| Abstract: | Background NASP (Nuclear Autoantigenic Sperm Protein) is a histone chaperone that is present in all dividing cells. NASP has two splice
variants: tNASP and sNASP. Only cancer, germ, transformed, and embryonic cells have a high level of expression of the tNASP
splice variant. We examined the consequences of tNASP depletion for prostate cancer PC-3 cells. |
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