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Enhanced Sensitivity of Surface Plasmon Resonance Phase-Interrogation Biosensor by Using Silver Nanoparticles
Authors:Tzu-Cheih Peng  Wen-Chi Lin  Chih-Wei Chen  Din Ping Tsai  Hai-Pang Chiang
Institution:(1) Institute of Optoelectronic Sciences, National Taiwan Ocean University, No. 2 Pei-Ning Rd, 202 Keelung, Taiwan;(2) Department of Physics, National Taiwan University, Taipei, Taiwan;(3) Institute of Physics, Academia Sinica, Taipei, Taiwan;(4) Instrument Technology Research Center, National Applied Research Laboratories, Hsinchu, Taiwan;
Abstract:It is demonstrated that the sensitivity of surface plasmon resonance phase-interrogation biosensor can be enhanced by using silver nanoparticles. Silver nanoparticles were fabricated on silver films by using thermal evaporation. Sizes of silver nanoparticles on silver thin film can be tuned by controlling the deposition parameters of thermal evaporation. By using surface plasmon resonance heterodyne interferometey to measure the phase difference between the p and s polarization of incident light, we have demonstrated that sensitivity of glucose detection down to the order of 10−8 refractive index units can be obtained.
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