Effect of histone on the nucleolar morphology of cells cultured in vitro |
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| Authors: | I Raška E Řeřábková J Hořejší K Smetana |
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| Institution: | (1) Laboratory for Ultrastructure Research of Cells and Tissues of the Czechoslovak Academy of Sciences, Czechoslovakia;(2) Institute of Hematology and Blood Transfusion, Prague, Czechoslovakia |
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| Abstract: | Summary The frequency of various types of nucleoli was investigated in tissue cultures of human embryonal lung and HeLa cells cultured in the presence of calf thymus histone. The nucleolar morphology and the frequency of various nucleolar types were dependent on the concentration of histone in the tissue cultures of the human embryonal lung cells. HeLa cells required longer cultivation with histone to manifest some effect on nucleoli. In both cases, the observed nucleolar changes suggest the depression of nucleolar RNA synthesis. |
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| Keywords: | Nucleoli Type Influence of histone Tissue culture Electron microscopy |
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