Tissue specific changes in DNA, RNA and protein content during late fetal and postnatal development in the rat |
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| Authors: | A Kistler |
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| Affiliation: | 1. Advanced Materials Institute for BIN Convergence (BK 21 Plus Global), Department of BIN Convergence Technology, Chobbuk National University, 561-761, Republic of Korea;2. Department of Chemistry (Affiliated toTribhuvan University), Kailali Multiple Campus, Dhangadhi, Kailali, Nepal;3. Department of Organic Materials and Fiber Engineering, Chonbuk National University, Jeonju, Republic of Korea;1. University of Heidelberg, Department of Sport and Exercise Psychology, Im Neuenheimer Feld 720, D-69120 Heidelberg, Germany;2. German Sport University Cologne, Institute of Cognitive and Team/Racket Sport Research, Am Sportpark Müngersdorf 6, D-50933 Köln, Germany;1. GREiA Research Group, INSPIRES Research Centre, University of Lleida, Pere de Cabrera s/n, 25001 Lleida, Spain;2. Department of Mechanical Engineering and Construction, Universitat Jaume I, Campus del Riu Sec s/n, 12071 Castelló de la Plana, Spain;3. Department of Nuclear Engineering, Tokyo Institute of Technology, 2-12-1-N1-22, O-okayama, Meguro-ku, Tokyo 152-8550, Japan;4. Laboratory for Advanced Nuclear Energy, Institute of Innovative Research, Tokyo Institute of Technology, 2-12-1-N1-22, Ookayama, Meguro-ku, Tokyo 152-8550, Japan;1. State Key Laboratory of Automotive Safety and Energy, Tsinghua University, Beijing 100084, China;2. Institute of Nuclear and New Energy Technology, Tsinghua University, Beijing 100084, China |
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| Abstract: | - 1.1. The levels of DNA, RNA, and protein in brain, heart, kidney, lung, liver and spleen have been studied in the rat during late fetal, peri- and postnatal development.
- 2.2. The protein/DNA ratio increased with age in all tissues tested, supporting the view that the ratio of cytoplasm to nucleus increases with differentiation.
- 3.3. A tissue specific pattern of the RNA/DNA ratio was observed with, however, highest and lowest values at quite different developmental stages.
- 4.4. The possible relationships between the developmental changes in the macromolecular constituents and morphological, biochemical and functional changes in the various tissues have been discussed.
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