|
|||||
|
|
Novel selective biocatalytic deacetylation studies on dihydropyrimidinones |
|
| Authors: | Ashok K Prasad Chandrani Mukherjee Sunil K Singh Raju Brahma Rajpal Singh Rajendra K Saxena Carl E Olsen Virinder S Parmar |
| Institution: | aBioorganic Laboratory, Department of Chemistry, University of Delhi, Delhi 110 007, India bCFEES, Brig. S.K. Mazumdar Road, Timarpur, Delhi 110 054, India cDepartment of Microbiology, University of Delhi South Campus, New Delhi 110 067, India dChemistry Department, Royal Veterinary and Agricultural University, DK-1871 Frederiksberg C, Copenhagen, Denmark |
| Abstract: | Five racemic ethyl 4-(3/4-acetoxyphenyl)-6-methyl-3,4-dihydropyrimidin-2-one-5-carboxylates have been synthesized by acetylation of corresponding hydroxy analogues, which in turn have been synthesized under microwave condition by multi-component Biginelli cyclocondensation of ethyl acetoacetate, urea and the corresponding hydroxybenzaldehydes in the presence of ferric chloride. These dihydropyrimidinones have been subjected to biocatalytic resolution using acetoxyl group on the phenyl ring as remote handle; Novozyme®-435, an immobilized lipase from Candida antarctica in THF:DIPE has been found to catalyze the deacetylation reactions in an enantioselective fashion. |
| Keywords: | 4-Phenyl-3 4-dihydropyrimidinones Biocatalysis Novozyme-435 Enantioselective deacetylation |
| 本文献已被 ScienceDirect 等数据库收录！ | |