The Fragilis interferon-inducible gene family of transmembrane proteins is associated with germ cell specification in mice |
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| Authors: | UC?Lange M?Saitou PS?Western SC?Barton Email author" target="_blank">MA?SuraniEmail author |
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| Institution: | (1) Wellcome Trust/Cancer Research UK Institute of Cancer and Developmental Biology, University of Cambridge, Tennis Court Road, CB2 1QR Cambridge, UK |
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| Abstract: | Background Specification of primordial germ cells in mice depends on instructive signalling events, which act first to confer germ cell
competence on epiblast cells, and second, to impose a germ cell fate upon competent precursors. fragilis, an interferon-inducible gene coding for a transmembrane protein, is the first gene to be implicated in the acquisition of
germ cell competence. |
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