Structure determination of human Lck unique and SH3 domains by nuclear magnetic resonance spectroscopy |
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| Authors: | Lars?Briese Email author" target="_blank">Dieter?WillboldEmail author |
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| Institution: | 1.Institut für Molekulare Biotechnologie,Jena,Germany;2.IBI-2, Forschungszentrum Jülich,Jülich,Germany;3.Institut für Physikalische Biologie,Heinrich-Heine-Universit?t,Düsseldorf,Germany |
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| Abstract: | Background Protein tyrosine kinases are involved in signal transduction pathways that regulate cell growth, differentiation, activation
and transformation. Human lymphocyte specific kinase (Lck) is a 56 kDa protein involved in T-cell- and IL2-receptor signaling.
Three-dimensional structures are known for SH3, SH2 and kinase domains of Lck as well as for other tyrosine kinases. No structure
is known for the unique domain of any Src-type tyrosine kinase. |
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